How to initiate treatment with CRESTOR

CRESTOR 10 mg is the appropriate start dose for most patients as it will enable them to reach their LDL-C goal.1,2,8,37

CRESTOR 5 mg is the flexible option for selected patients*.

Titrating CRESTOR

A dose adjustment from 5 to 10 mg or from 10 to 20 mg can be made after 4weeks, if necessary. Patients with severe hypercholesterolaemia and at highcardiovascular risk who do not achieve their LDL-C goal with CRESTOR 20 mg andare not contraindicated for the highest dose, may be titrated to the maximumdose of CRESTOR 40 mg after an additional 4 weeks. Specialist supervision isrecommended if increasing the dose from 20 to 40 mg.

* Selected patients for 5 mg

The choice of start dose should take into account individual patient’scholesterol level and future cardiovascular risk as well as their potentialrisk for adverse reactions. The 5 mg start dose is recommended for patients whohave predisposing factors for myopathy:

• renal impairment
  
• hypothyroidism
  
• personal or family history of hereditary muscular disorders
  
• previous history of muscular toxicity with another HMG-CoA reductase inhibitor or fibrate
  
• alcohol abuse
  
• age >70 years
  
• situations where an increase in plasma levels may occur e.g. Asian patients
  
• concomitant use of fibrates.

Always remember to see local prescribing information for full details beforeinitiating CRESTOR, as prescribing information may vary from country tocountry.

>>Read the international prescribinginformation