Benefit of lowering cholesterol
Large-scale intervention trials have shown a clear relationship between reduction of cholesterol (by any means) and reduction in both mortality, due to coronary heart disease, and total mortality. This kind of data has driven guideline bodies to more aggressive recommendations for treatment. Meta-analysis of 38 primary and secondary prevention trials, with more than 98,000 patients in total.
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Efficacy
Clinical research
The best surrogate data will translate into the best clinical outcomes seen so far with statin
therapy.